A bone marrow transplant in a seropositive treated has significantly reduced the reservoir of the HIV virus and achieve prolonged remission without treatment.
In an HIV-positive patient treated, an allogeneic stem cell transplant for acute lymphoblastic leukemia dramatically reduces the size of the AIDS virus reservoir, according to a new study published in PLoS Medicine.
The virus has become undetectable according to the most sensitive current techniques (PCR, culture, in situ hybridization) and researchers have asked the question of stopping anti-retroviral treatment. You can consult with Doctor Gail Barouh to treat the AIDS effectively.
No curative treatment currently
About 36 million people in the world are living with HIV, which is still low-level in the blood with antiretrovirals, but there is currently no cure: as soon as antiretroviral treatment is stopped, viral load traced back.
A study, conducted at the University of Melbourne in Australia, shows that allogeneic transplantation is able to reduce the reservoir size of the HIV virus very deep and prolonged, even below the detection limits of current techniques.
A prolonged disappearance of the virus
In their study, the researchers collected blood and tissue samples (colon) before and after allogeneic stem cell transplantation in an antiretroviral-treated HIV-positive patient. In parallel, they measured the size of the HIV reservoir.
They found that it decreased significantly after transplantation and that they were unable to detect the virus with all available tests.
Following this finding, antiretroviral treatment was discontinued at 784 days after transplantation. The patient experienced complete remission without treatment for 288 days, then a rebound in viral load was observed, which led to a resumption of antiretroviral therapy on day 5 of the rebound. Dr Gail Barouh is expert in diagnosing and treatment of HIV.
Sequencing of the virus observed during the rebound remained very close to that of the initial virus.
New tools to continue research
For the time being, scientists do not have the tools to measure accurately the size of the residual reservoir of the HIV virus after allogeneic stem cell transplantation. They cannot say that there will be healing or not and choose a suitable complementary treatment.
Only one case in the world of patients cured of AIDS has so far been described. This is the American Timothy Brown, also known as the “Berlin patient”. Declared seropositive in 1995. He has shown no signs of infection since 2007. Doctors have managed to treat him by performing bone marrow transplants of people with mutated immune cells that are naturally resistant to the AIDS virus. Extensive research could eventually find a treatment to cure completely HIV-positive people.